Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure.
Identifieur interne : 000D25 ( Main/Exploration ); précédent : 000D24; suivant : 000D26Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure.
Auteurs : Roman Schniepp [Allemagne] ; Maximilian Wuehr ; Maximilian Neuhaeusser ; Maria Kamenova ; Konstantin Dimitriadis ; Thomas Klopstock ; M. Strupp ; Thomas Brandt ; Klaus JahnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- complications : Cerebellar Ataxia, Vestibular Diseases.
- etiology : Gait Disorders, Neurologic.
- physiology : Locomotion, Posture.
- Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.
DOI: 10.1002/mds.23978
PubMed: 21997342
Affiliations:
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Strupp</name></author><author><name sortKey="Brandt, Thomas" sort="Brandt, Thomas" uniqKey="Brandt T" first="Thomas" last="Brandt">Thomas Brandt</name></author><author><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.23978</idno><idno type="RBID">pubmed:21997342</idno><idno type="pmid">21997342</idno><idno type="wicri:Area/PubMed/Corpus">000F99</idno><idno type="wicri:Area/PubMed/Curation">000F99</idno><idno type="wicri:Area/PubMed/Checkpoint">000D55</idno><idno type="wicri:Area/Ncbi/Merge">003431</idno><idno type="wicri:Area/Ncbi/Curation">003431</idno><idno type="wicri:Area/Ncbi/Checkpoint">003431</idno><idno type="wicri:Area/Main/Merge">000D47</idno><idno type="wicri:Area/Main/Curation">000D25</idno><idno type="wicri:Area/Main/Exploration">000D25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure.</title><author><name sortKey="Schniepp, Roman" sort="Schniepp, Roman" uniqKey="Schniepp R" first="Roman" last="Schniepp">Roman Schniepp</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Munich, Munich, Germany. roman.schniepp@med.uni-muenchen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Wuehr, Maximilian" sort="Wuehr, Maximilian" uniqKey="Wuehr M" first="Maximilian" last="Wuehr">Maximilian Wuehr</name></author><author><name sortKey="Neuhaeusser, Maximilian" sort="Neuhaeusser, Maximilian" uniqKey="Neuhaeusser M" first="Maximilian" last="Neuhaeusser">Maximilian Neuhaeusser</name></author><author><name sortKey="Kamenova, Maria" sort="Kamenova, Maria" uniqKey="Kamenova M" first="Maria" last="Kamenova">Maria Kamenova</name></author><author><name sortKey="Dimitriadis, Konstantin" sort="Dimitriadis, Konstantin" uniqKey="Dimitriadis K" first="Konstantin" last="Dimitriadis">Konstantin Dimitriadis</name></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name></author><author><name sortKey="Strupp, M" sort="Strupp, M" uniqKey="Strupp M" first="M" last="Strupp">M. Strupp</name></author><author><name sortKey="Brandt, Thomas" sort="Brandt, Thomas" uniqKey="Brandt T" first="Thomas" last="Brandt">Thomas Brandt</name></author><author><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Cerebellar Ataxia (complications)</term><term>Female</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Locomotion (physiology)</term><term>Male</term><term>Middle Aged</term><term>Posture (physiology)</term><term>Statistics, Nonparametric</term><term>Vestibular Diseases (complications)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cerebellar Ataxia</term><term>Vestibular Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Locomotion</term><term>Posture</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><noCountry><name sortKey="Brandt, Thomas" sort="Brandt, Thomas" uniqKey="Brandt T" first="Thomas" last="Brandt">Thomas Brandt</name><name sortKey="Dimitriadis, Konstantin" sort="Dimitriadis, Konstantin" uniqKey="Dimitriadis K" first="Konstantin" last="Dimitriadis">Konstantin Dimitriadis</name><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name><name sortKey="Kamenova, Maria" sort="Kamenova, Maria" uniqKey="Kamenova M" first="Maria" last="Kamenova">Maria Kamenova</name><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><name sortKey="Neuhaeusser, Maximilian" sort="Neuhaeusser, Maximilian" uniqKey="Neuhaeusser M" first="Maximilian" last="Neuhaeusser">Maximilian Neuhaeusser</name><name sortKey="Strupp, M" sort="Strupp, M" uniqKey="Strupp M" first="M" last="Strupp">M. Strupp</name><name sortKey="Wuehr, Maximilian" sort="Wuehr, Maximilian" uniqKey="Wuehr M" first="Maximilian" last="Wuehr">Maximilian Wuehr</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Schniepp, Roman" sort="Schniepp, Roman" uniqKey="Schniepp R" first="Roman" last="Schniepp">Roman Schniepp</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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